Research

Development of Lysin-Chitosan Functionilazed Therapeutic Polymer Against Group B Streptococci
Professor SR Moyo, Dr G Nyanhongo, Dr R Mavenyengwa, Professor B Noden
GBS Study Group
Department of Bio-medical Sciences
2011-2014

In view of the escalating resistance to GBS isolates worldwide and lack of a potent vaccine to deal with infections caused by this organism, other innovative ways of treatment for this organism have to be sought. It is envisaged that this study will result in the development of an alternative and potent method of therapy against GBS by use of phage lysine-chitosan functionalised therapeutic polymer. Considering that phage lysins limit the spread of infection and kill targeted bacteria on contact, the development of chitosan based lysins/holins polymers could be used as components of antibacterial sprays, gel or cream. These vaginal sprays, gel or cream applications containing immobilized lysins/and or holins could be an effective alternative to conventional antibiotic resistance and help selectively eliminate GBS without interfering with the normal vaginal flora.


Exposure to Zoonotic Diseases Among Namibian Blood Donors

Dr. Bruce Noden, Ms. Elzabe van der Colf

Department of Bio-medical Sciences
2011-2012

The influence of most Neglected Tropical Diseases (NTDs) in the Namibian population remains a mystery with few published indicators since independence. Because of the prevalence of ticks and flea exposure in Namibia due to high levels of cattle, sheep and goat production, two major port cities and the high pet: owner ratio of urban dwellers, it is hypothesized that zoonotic infectious diseases are prevalent but are considerably under-diagnosed because of the disproportionate focus on the Big Three (malaria, HIV, and TB). The objective of the proposed research is to conduct a ‘pilot study’ to evaluate the exposure to Bartonella, Rickettsia, and Coxiella of 300 volunteers identified by The Blood Transfusion Service of Namibia (NAM-BTS). Through this research, capacity will be built at the NUST, Biomedical Science students will receive valuable training, seroprevalence rates will be established among Namibian blood donors, and preliminary data will be gathered on which larger sero-studies can be developed.

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