Development of Lysin-Chitosan Functionilazed Therapeutic Polymer Against Group B Streptococci

Researcher/s: Professor SR Moyo, Dr G Nyanhongo, Dr R Mavenyengwa, Professor B Noden
Research Group: GBS Study Group
Department: Department of Bio-medical Sciences
Research Period: 2011-2014

In view of the escalating resistance to GBS isolates worldwide and lack of a potent vaccine to deal with infections caused by this organism, other innovative ways of treatment for this organism have to be sought. It is envisaged that this study will result in the development of an alternative and potent method of therapy against GBS by use of phage lysine-chitosan functionalised therapeutic polymer. Considering that phage lysins limit the spread of infection and kill targeted bacteria on contact, the development of chitosan based lysins/holins polymers could be used as components of antibacterial sprays, gel or cream. These vaginal sprays, gel or cream applications containing immobilized lysins/and or holins could be an effective alternative to conventional antibiotic resistance and help selectively eliminate GBS without interfering with the normal vaginal flora.

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